Signals
2,619 signals · +12 since yesterday
Paul Graham co-founded Y Combinator, which backed Airbnb and Stripe, then Supabase and Replit, now valued at $10.5Bn and $9Bn. His advice to founders: “Live in the future, then build what’s missing.” Our agents read the articles, the newsletters and the funding rounds, and you only get what moves a market, months before someone sells a $2,000 course on it. You get to live in the future. The building part is on AI.
Example. Signal logged October 23: 230+ romance-only bookstores have opened in the US in three years. It went straight into our trend Bookstore renaissance, home to ten business ideas.
Open the signal feedThe US midterm election campaign, with about $12B in political spending including $8.2B for linear and connected TV, is pushing regional brands out of local slots and raising premium CTV CPMs from $34-35 to $43.
Why it matters. This surge in ad prices driven by political money is shifting budgets toward streaming and raising costs across the whole video ad market at year-end.
PPC LandStreaming TV advertising
NBCUniversal is reportedly poised to take control of FreeWheel, the ad server used by many of its competitors, as part of Comcast's tax-neutral spin-off announced on June 29.
Why it matters. A broadcaster controlling the ad infrastructure used by its rivals raises the question of neutrality in the industry's advertising pipes.
PPC LandStreaming TV advertising
Rakuten Medical, the biotech subsidiary of Japanese conglomerate Rakuten, is running phase 3 clinical trials in the United States for its photoimmunotherapy cancer treatment and aims to file with the FDA in 2028, with 95% of its resources focused on the US market.
Why it matters. This is a therapeutic breakthrough that could open a fifth cancer treatment pathway alongside surgery, radiotherapy, chemotherapy and immunotherapy.
FortunePrecision Oncology Breakthroughs (Very Expensive)